Ethanol-induced jejunal microvascular and morphological injury in relation to histamine release in rabbits.
作者： Paritosh K. Dinda , Christine A. Holitzner , Gerald P. Morris , Ivan T. Beck
DOI: 10.1016/0016-5085(93)90402-X
关键词: Toxicity 、 Chemistry 、 Mast cell stabilizer 、 Internal medicine 、 Prostaglandin E2 、 Epithelial Damage 、 Phloretin 、 Endocrinology 、 Histamine 、 Prostaglandin E 、 Ketotifen
摘要: Abstract Background: To investigate the relation between ethanol-induced jejunal microvascular injury, morphological changes, and histamine release, present study examined whether attenuation of effect ethanol by 16,16-dimethyl prostaglandin E 2 (dmPGE ) (reported us previously) was associated with an epithelial damage release. Methods: Rabbits were used. Mucosal injury assessed determining plasma protein loss (JPPL), release measuring concentration gut effluent, routine histology. Results: (1) During 90-minute perfusion, there a direct time course that JPPL. (2) dmPGE attenuated JPPL decrease in directly proportional to (3) did not alleviate damage. (4) Ketotifen (a mast cell stabilizer), similar , (5) Ethanol caused jejunum vitro; this also phloretin stabilizer). Conclusions: It appears causes inducing mediators from mucosal cells. attenuates stabilizing The is related but
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