Effects of chronic alcohol abuse on duodenal mononuclear cells in man.

摘要: The aim of this study was to investigate whetherchronic alcohol abuse alters the number and distributionof mononuclear cells duodenal mucosa. numberof common leukocyte antigen (CLA)-positive interepithelial lymphocytes (IEL), Blymphocytes (BL), IgAproducing plasma (IgA-PC),and macrophages (MP) quantitatively evaluated inbiopsies mucosa patients with alcoholabuse compared subjects without abuse.Biopsies from descending part duodenum wereobtained by endoscopy two groups withchronic (group A1, abstinence <5 days, N = 21) group A2 abstaining 5-10 days(N 6). Twenty-five abuseserved as controls (C). Immunohistochemical staining wasdone avidinbiotin- complex method. In addition, content IgA in wasdetermined using a TV-densitometric Thenumber B-lymphocytes lamina propria wasincreased 37% A1 (P < 0.005). A distinctdecrease observed C thenumber IEL that were CLA positive (–50%, P <0.025) (–54%, P< 0.025). differences B no longerseen. there significant change IgA-producing or ofinterepithelial counted after H&E controls. There nodifference plasmacells. From these results it is concluded chronicalcohol significantly influences gut-associated immune system, possibly byincreasing permeability gut tomacromolecules act antigens.