Fecal calprotectin concentrations in alcoholic patients: a longitudinal study

摘要: OBJECTIVES: Excessive alcohol consumption often results in intestinal damage, mediated by inflammatory processes, mainly characterized an increased influx of leukocytes. Fecal calprotectin is a granulocyte cytosolic protein, representing as promising marker subclinical inflammation. In this study, we assessed fecal concentrations (FCCs) current drinking alcoholics, both at the baseline, and then during subsequent 84-day period. Moreover, FCCs alcoholics were compared with healthy controls. METHODS: Twenty-eight, active-drinking enrolled study 40 volunteers control group. determined beginning (baseline; T0) every 2 weeks (T1-T6) following Potential differences analyzed between controls, period within group alcoholics. addition, analysis was conducted three subgroups considering their status (abstinent, relapsed, active). RESULTS: At no significant median found controls. No changes found, comparing baseline whole nor alcoholics. CONCLUSION: are not significantly different, do differ according to status. These may suggest absence subclinal inflammation involving neutrophils