Jejunal immunoglobulin secretion in alcoholic patients with and without cirrhosis
作者： J.F. Colombel , J.P. Vaerman , B. Mesnard , J.P. Dehennin , C. Dive
DOI: 10.1016/0168-8278(91)90930-A
关键词:
摘要: Alcoholic liver diseases are associated with an elevation of serum immunoglobulin A (IgA). This could be the result increased IgA production by intestinal mucosa. Serum and jejunal immunoglobulin, albumin orosomucoid were measured in 13 alcoholic patients (n = 6) without 7) cirrhosis compared to 11 controls. Jejunal secretions obtained segmental perfusion under occluding balloon. High levels monomeric polymeric only found cirrhosis. Alcoholics had normal secretion rates. clearances albumin, G significantly higher both non-cirrhotic cirrhotic than These findings indicate permeability plasma proteins, such as alcoholics.
journal-of-hepatology.eu
elsevier.com
sci-hub.se 参考文章(28)
William H Kutteh, Shirley J Prince, John O Phillips, Jerry G Spenney, Jiri Mestecky, None, Properties of immunoglobulin A in serum of individuals with liver diseases and in hepatic bile Gastroenterology. ,vol. 82, pp. 184- 193 ,(1982) , 10.1016/0016-5085(82)90003-8
Hjf. Hodgson, Dominique L. Delacroix, J. Kalsi, IgA in alcoholic cirrhosis. Clinical and Experimental Immunology. ,vol. 52, pp. 499- 504 ,(1983)
Milan Tomana, Rose Kulhavy, Jiri Mestecky, Receptor-mediated binding and uptake of immunoglobulin a by human liver Gastroenterology. ,vol. 94, pp. 762- 770 ,(1988) , 10.1016/0016-5085(88)90252-1
JH Perez, DGD Wight, M van Schaik, BM Mullock, JP Luzio, None, The polymeric immunoglobulin receptor is present on hepatocytes in human liver Advances in Mucosal Immunology. ,vol. 68, pp. 594- 595 ,(1990) , 10.1007/978-94-009-1848-1_182
Mikael G. Buell, Ivan T. Beck, Ethanol-Induced Mucosal Microvascular Stasis and Enhanced Plasma Protein Loss in the Dog Jejunum Gastroenterology. ,vol. 86, pp. 413- 420 ,(1984) , 10.1016/S0016-5085(84)80010-4
Gilles Pomier-Layrargues, Pierre-Michel Huet, Gilles Richer, Denis Marleau, Andr� Viallet, Hyperglobulinemia in alcoholic cirrhosis Digestive Diseases and Sciences. ,vol. 25, pp. 489- 493 ,(1980) , 10.1007/BF01315210
William R. Brown, Thomas M. Kloppel, The liver and IgA: immunological, cell biological and clinical implications. Hepatology. ,vol. 9, pp. 763- 784 ,(1989) , 10.1002/HEP.1840090518
Ingvar Bjarnason, Kevin Ward, TimothyJ Peters, THE LEAKY GUT OF ALCOHOLISM: POSSIBLE ROUTE OF ENTRY FOR TOXIC COMPOUNDS The Lancet. ,vol. 323, pp. 179- 182 ,(1984) , 10.1016/S0140-6736(84)92109-3
J F Colombel, R Hallgren, P Venge, B Mesnard, J C Rambaud, Neutrophil and eosinophil involvement of the small bowel affected by chronic alcoholism. Gut. ,vol. 29, pp. 1656- 1660 ,(1988) , 10.1136/GUT.29.12.1656
A. WIEL, W. F. SEIFERT, J. A. LINDEN, F. H. J. GMELIG-MEYLING, L. KATER, H. -J. SGHUURMAN, Spontaneous IgA synthesis by blood mononuclear cells in alcoholic liver disease. Scandinavian Journal of Immunology. ,vol. 25, pp. 181- 187 ,(1987) , 10.1111/J.1365-3083.1987.TB01062.X