Reversal of Isolation Rearing-Induced Deficits in Prepulse Inhibition by Seroquel and Olanzapine

摘要: Abstract Background: Prepulse inhibition (PPI) of startle provides an operational measure sensorimotor gating in which a weak stimulus presented prior to startling reduces the response. PPI deficits observed schizophrenia patients can be modeled rats by individual housing from weaning until adulthood. Deficits produced isolation rearing reversed antipsychotics. Methods: We evaluated ability Seroquel and olanzapine reverse isolation-induced disruption PPI. Rats housed for 8 weeks singly or groups 3 were tested every 2 after either (0, 5.0 mg/kg) 2.5, mg/kg). Startle was elicited 120-dB pulses with without prepulses (3, 6, 12 dB above 65-dB background). Results: Isolation repeatedly disrupted sometimes increased reactivity. these affecting socially reared controls. Olanzapine (2.5 rearing-induced deficit tended increase basal levels. Both antipsychotics antagonized Conclusions: produces that are reversible atypical antipsychotics, may therefore aid identifying new treatments schizophrenia.