Negative visuospatial priming in isolation-reared rats: Evidence of resistance to the disruptive effects of amphetamine

摘要: Negative visuospatial priming (NP) represents a quantifiable measure of inhibitory information processing that is disrupted in several neurodevelopmental and psychiatric disorders, including schizophrenia. We developed novel rodent NP task to investigate mechanisms underlying its role various test potential therapeutics. In the present studies, we further characterized this paradigm by investigating whether rats reared isolation, developmental manipulation produces range abnormalities behavior, neurochemistry, brain structure mirror aspects schizophrenia pathology. also explored monoaminergic signaling effects isolation rearing challenging both socially isolation-reared with D-amphetamine during task. Although fewer animals learned complex task, those exhibited unaffected compared rats. Consistent previous reports, impaired increased motor impulsivity contrast, did not affect or These data confirm influence on behavior indicate have altered dopaminergic sensitivity.