Psychosocial factors in the neurobiology of schizophrenia: a selective review.

摘要: Aim Various forms of social adversity have been implicated in the development and emergence psychosis. However, how when these events exert their influences are not clear. In this paper, we attempt to examine putative psychosocial factors place them a temporal context propose neurobiological mechanism linking factors. Methods Medline databases were searched between 1966 2007 followed by cross-checking references using following keywords: psychosocial, stress, stressors, life events, psychological, combined with psychosis schizophrenia. Results While some findings conflicting, there number positive studies which suggest that like prenatal urban birth childhood trauma accentuate vulnerability for schizophrenia other psychoses while migration particularly being minority group, high expressed emotions, occur later vulnerable individual may move towards tipping point Conclusion Overall, is evidence implicate pathophysiology These act via common pathway, involves stress-induced dysregulation HPA axis dopaminergic systems. To establish causal relationship various would require prospective adequately powered.