Preparation and characterization of interpenetrating hydrogel for colon drug delivery
作者： S Kumari
DOI:
关键词: Drug release kinetics 、 Polymer chemistry 、 Self-healing hydrogels 、 Drug delivery 、 Xanthan gum 、 Swelling 、 Drug release 、 Materials science 、 Nuclear chemistry 、 Gastrointestinal system 、 Polysaccharide
摘要: This thesis work is based on preparation and characterization of Interpenetrating (IPN) hydrogels poly (HEMA) with polysaccharides (xanthan gum or isabgol). IPN were prepared by cross-linking the HEMA in presence varying concentration xanthan isabgol. The concentrations used for this purpose 0.1% (w/v), 0.3% (w/v),0.5% (w/v) 0.7% whereas isabgol selected 1% 2% 3% 4% (w/v). either mixed proportion 30:70 (w/w) before being croslinked using APS TEMED. characterized swelling tests at Ph 1.2, pH 7 9.Physical properties assessed XRD FTIR. Suitability its application as colon drug delivery system (CDDS) was incorporating curcumin in-vitro release kinetics assay simulated condition gastrointestinal system. found to swell maximal rate be highest 6.8 indicating potential CDDS.
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