Autocrine Hepatocyte Growth Factor Provides a Local Mechanism for Promoting Axonal Growth
作者： Xiu-Ming Yang , Jean G. Toma , Shernaz X. Bamji , Daniel J. Belliveau , Judi Kohn
DOI: 10.1523/JNEUROSCI.18-20-08369.1998
关键词: Endocrinology 、 Receptor 、 Internal medicine 、 Cell biology 、 Neurotrophin 、 Superior cervical ganglion 、 Chemistry 、 Autocrine signalling 、 Growth factor receptor inhibitor 、 Neuron 、 Hepatocyte growth factor 、 Tyrosine kinase
摘要: In this report, we describe a novel local mechanism necessary for optimal axonal growth that involves hepatocyte factor (HGF). Sympathetic neurons of the superior cervical ganglion coexpress bioactive HGF and its receptor, Met tyrosine kinase, both in vivo vitro. Exogenous selectively promotes but not survival cultured sympathetic neurons; magnitude effect is similar to observed with exogenous NGF. Conversely, antibodies inhibit endogenous decrease neuron have no on survival. This autocrine required locally by axons growth, as demonstrated using compartmented cultures. Thus, provides local, intrinsic promoting neuronal without affecting survival, role may be essential during developmental axogenesis or after injury.
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