Comparison of cerebral blood volume and permeability in preoperative grading of intracranial glioma using CT perfusion imaging

摘要: Regional cerebral blood volume (rCBV) and permeability surfaces (rPS) permit in vivo assessment of glioma microvasculature, which provides quite important pathophysiological information grading gliomas. The aim our study was to simultaneously examine rCBV rPS patients determine their correlation with histological grade using CT perfusion imaging. A total 22 gliomas underwent multislice imaging preoperatively. Low-grade high-grade groups were categorized corresponding WHO II III or IV gliomas, respectively, as determined by histopathological examination. rCBVs rPSs obtained from regions maximal abnormality tumor parenchyma on CBV PS color maps. Perfusion parameters compared the Kruskal-Wallis test order evaluate differences relation grade. Pearson coefficients for each assessed SPSS 13.0 software. provided significant P-value differentiating (low-grade 3.28±2.01 vs 2.12±3.19 ml/100 g/min, 8.87±4.63 12.11±3.18 ml/100 g/min, P<0.05). Receiver operating characteristic (ROC) curves revealed better specificity sensitivity than between observed (r=0.684). oligodendrogliomas higher other low-grade whereas values did not show a parallel difference. useful might have potential significantly impact clinical management follow-up