Derivation and validation of a simple, accurate and robust prediction rule for risk of mortality in patients with Clostridium difficile infection.

摘要: Clostridium difficile infection poses a significant healthcare burden. However, the derivation of simple, evidence based prediction rule to assist patient management has not yet been described. This study aimed identify such stratify hospital inpatients according risk all-cause mortality, at initial diagnosis infection. Univariate, multivariate and decision tree procedures were used deduce from over 186 variables; retrospectively collated clinical data for 213 patients. The resulting was validated on independent cohort 158 patients described by Bhangu et al. (Colorectal Disease, 12(3):241-246, 2010). Serum albumin levels (g/L) (P = 0.001), respiratory rate (resps /min) (P = 0.002), C-reactive protein (mg/L) (P = 0.034) white cell count (mcL) (P = 0.049) predictors mortality. Threshold serum albumin ≤ 24.5 g/L, C- reactive >228 mg/L, >17 resps/min >12 × 103 mcL associated with an increased A simple four variable devised these threshold when tested data, yield area under curve score 0.754 (P < 0.001) using receiver operating characteristics. then evaluated 0.653 (P = 0.001). Four easily measurable variables can be assess mortality remains robust respect data.