Elucidating the mechanisms of transcription regulation during heart development by next-generation sequencing
作者： Keisuke Nimura , Yasufumi Kaneda
DOI: 10.1038/JHG.2015.84
关键词: Human genetics 、 Gene 、 Transcription (biology) 、 Epigenetics 、 Heart development 、 Genetics 、 Transcriptional regulation 、 Transcription factor 、 Chromatin 、 Computational biology 、 Biology
摘要: Dysregulation of transcription is associated with the pathogenesis cardiovascular diseases, including congenital heart diseases and failure. However, it remains unclear how factors regulate in which genes are humans. Development genome-wide analyses using next-generation sequencers provides powerful methods to determine these chromatin regulators control gene expressions identify causative diseases. These technologies have revealed that during development elaborately regulated by multiple cardiac factors. In this review, we discuss recent progress toward understanding molecular mechanisms transcriptional dysregulation leads
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