Tbx5 is required for forelimb bud formation and continued outgrowth.

作者: Charalampos Rallis , Benoit G Bruneau , Jo Del Buono , Christine E Seidman , JG Seidman

DOI: 10.1242/DEV.00473

关键词: Zone of polarizing activityAnatomyConditional gene knockoutForelimbBiologyApical ectodermal ridgeHeart malformationLimb budHindlimbCell biologyLimb development

摘要: … at early limb bud stages for forelimb bud development. In … stages of limb bud development for continued limb outgrowth. Our … demonstrate that limb bud outgrowth and specification of …

参考文章(61)
Ann Campbell Burke, Hox genes and the global patterning of the somitic mesoderm. Current Topics in Developmental Biology. ,vol. 47, pp. 155- 181 ,(2000) , 10.1016/S0070-2153(08)60725-5
Matthew H. Kaufman, The Atlas of Mouse Development ,(1992)
Keisuke Sekine, Hideyo Ohuchi, Masanori Fujiwara, Masahiro Yamasaki, Tatsuya Yoshizawa, Takashi Sato, Naoko Yagishita, Daisuke Matsui, Yoshihiko Koga, Nobuyuki Itoh, Shigeaki Kato, Fgf10 is essential for limb and lung formation Nature Genetics. ,vol. 21, pp. 138- 141 ,(1999) , 10.1038/5096
Jun K. Takeuchi, Kazuko Koshiba-Takeuchi, Ken Matsumoto, Astrid Vogel-Höpker, Mayumi Naitoh-Matsuo, Keiko Ogura, Naoki Takahashi, Kunio Yasuda, Toshihiko Ogura, Tbx5 and Tbx4 genes determine the wing/leg identity of limb buds. Nature. ,vol. 398, pp. 810- 814 ,(1999) , 10.1038/19762
Ohad S. Birk, Delane E. Casiano, Christopher A. Wassif, Tiziana Cogliati, Liping Zhao, Yangu Zhao, Alexander Grinberg, SingPing Huang, Jordan A. Kreidberg, Keith L. Parker, Forbes D. Porter, Heiner Westphal, The LIM homeobox gene Lhx9 is essential for mouse gonad formation. Nature. ,vol. 403, pp. 909- 913 ,(2000) , 10.1038/35002622
Tohru Tsukui, Sayuri Yonei, Jorge Magallon, Koji Tamura, Juan Carlos Izpisua Belmonte, Concepción Rodriguez-Esteban, The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity. Nature. ,vol. 398, pp. 814- 818 ,(1999) , 10.1038/19769
Madeleine Gumpel-Pinot, D. A. Ede, O. P. Flint, Myogenic cell movement in the developing avian limb bud in presence and absence of the apical ectodermal ridge (AER) Development. ,vol. 80, pp. 105- 125 ,(1984) , 10.1242/DEV.80.1.105
Concepción Rodriguez-Esteban, Muriel Altabef, Cheryll Tickle, Tohru Tsukui, Aimee Ryan, Alison Isaac, Ketan Patel, Juan-Carlos Izpisúa-Belmonte, Tbx genes and limb identity in chick embryo development Development. ,vol. 125, pp. 1867- 1875 ,(1998)
J.B. Jaynes, P.H. O'Farrell, Active repression of transcription by the engrailed homeodomain protein. The EMBO Journal. ,vol. 10, pp. 1427- 1433 ,(1991) , 10.1002/J.1460-2075.1991.TB07663.X
C. Tabin, E. Laufer, E. DiMambro, B.A. Morgan, A.C. Burke, L.C. Murtaugh, L.F. Parada, C.E. Nelson, E. Gonzales, L. Tessarollo, Analysis of Hox gene expression in the chick limb bud Development. ,vol. 122, pp. 1449- 1466 ,(1996) , 10.1242/DEV.122.5.1449