Growth factors and cytokines/chemokines as surrogate biomarkers in cerebrospinal fluid and blood for diagnosing Alzheimer’s disease and mild cognitive impairment
作者： Lars Olson , Christian Humpel
DOI: 10.1016/J.EXGER.2009.10.011
关键词: Chemokine 、 Medicine 、 Dementia 、 Cerebrospinal fluid 、 Disease 、 Immunology 、 Cytokine 、 Growth factor 、 Pathological 、 Biomarker (medicine)
摘要: Alzheimer's disease (AD) is a severe chronic neurodegenerative disorder of the brain. A probable diagnosis AD can be obtained by cerebrospinal fluid levels 3 biomarkers: beta-amyloid (1-42), total tau and phospho-tau181. Researchers are interested in finding additional biomarkers CSF to improve specificity sensitivity diagnosis, including also other forms dementia, such as mild cognitive impairment (MCI). In addition, less invasive diagnostic methods using blood or blood-derived cells being investigated. This mini-review (in concert with reviews this special issue) summarizes usefulness growth factors cytokines/chemokines putative surrogate for diagnosing MCI blood. Briefly, expression very heterogenous, indicating pathological diversity these diseases. At present, no single factor cytokine alone stands out useful biomarker MCI. However, combined "patients profile signature" several selected and/or may allow diagnose higher selectively specificity.
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