Dose‐response efficacy of caraway (Carum carvi L.) on tissue lipid peroxidation and antioxidant profile in rat colon carcinogenesis
作者： Muthaiyan Kamaleeswari , Namasivayam Nalini
关键词: Glutathione peroxidase 、 Thiobarbituric acid 、 Glutathione reductase 、 Carum carvi 、 Ascorbic acid 、 Pharmacology 、 TBARS 、 Biochemistry 、 Antioxidant 、 Glutathione 、 Chemistry
摘要: Colon cancer is a leading cause of death and its prevention great interest throughout the world. This study was conducted to examine efficacy different doses dietary caraway (Carum carvi L.) on tissue lipid peroxidation (LPO) antioxidant profile in rat colon carcinogenesis. Wistar male rats were divided into 6 groups fed modified pellet diet for whole 30 weeks. To induce cancer, given weekly subcutaneous injection 1,2-dimethylhydrazine (DMH) at dose 20 mg kg(-1) (based body weight) first 15 Caraway supplemented every day orally 30, 60 90 total period All sacrificed end weeks, colons examined visually masses subsequently evaluated histologically. The results showed diminished levels intestinal, colonic caecal LPO products, such as conjugated dienes (CD), hydroperoxides (LOOH) thiobarbituric acid reactive substances (TBARS) also antioxidants superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) reductase (GR) DMH treated rats, which significantly reversed (P<0.05) supplementation. Moreover, enhanced activity peroxidase (GPx), S-transferase (GST) ascorbic alpha-tocopherol observed carcinogen-treated Thus, our that supplementation had modulatory role LPO, prevented DMH-induced histopathological lesions rats.
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