BHRF1, a viral homologue of the Bcl-2 oncogene, disturbs epithelial cell differentiation.

摘要: Epstein-Barr virus (EBV) is associated with tumours of both lymphoid and epithelial origin. Whilst a role for EBV latent genes in the development these malignancies accepted, it also possible that viral proteins involved replication may influence oncogenic process. BHRF1 an immediate early protein which has homology Bcl-2 oncogene can protect B cells from apoptosis. In vivo this most abundantly expressed upper layers oral 'hairy' leukoplakia (HL), benign hyperparakeratotic tongue lesion represents focus replication. We have transfected into human squamous cell carcinoma line SCC12F retains several features normal keratinocytes behaviour vitro. expression delay commitment to terminal differentiation, increased resistance DNA damaging drug, cis-platin enhanced survival under conditions serum deprivation. As differentiation apoptotic process, data strongly suggests delays through prevention This effect BHRF1, normally function promote productive infection, could contribute EBV-associated tumours.