Viral genes that modulate apoptosis

摘要: Viruses trigger a programmed cellular suicide pathway upon infection of cells in wide range organisms from mammals to bacteria. Programmed cell death response virus is presumably host defence mechanism an attempt eliminate infected and block spread the pathogen. activate by variety direct indirect mechanisms that are not yet fully understood. DNA viruses with large coding capacities have acquired genes avert cell’s die, leading successful completion viral replication cycle production progeny virus. The study these has led identification several families inhibit or delay acting at various points along pathway, blocking initiation receptor signalling inhibition caspases near final stages death. Viral apoptosis inhibitors may contribute pathogenesis other than increasing load. For example, anti-apoptotic proteins known participate transformation tumourigenesis. Thus, also human cancer.