Elevated synovial tissue concentration of the common acute lymphoblastic leukaemia antigen (CALLA)-associated neutral endopeptidase (3.4.24.11) in human chronic arthritis.

摘要: The cell-surface neutral endopeptidase 3.4.24.11 (NEP) activity of the common acute lymphoblastic leukaemia antigen (CALLA) cleaves diverse peptide mediators at specific sites and it has been postulated that regulates immune responses. concentration NEP was quantified in detergent extracts synovial tissues by percentage hydrolysis [3H-D-Ala]-Leu enkephalin/hr/100 mg tissue. tissue higher all patients with rheumatoid arthritis (n = 7; group mean +/- SD 29.4 20.2%), degenerative joint disease 6 8; 11.9 10.4%) than traumatic arthropathy 3; 1.1 0.7%). lack direct relationship between leukocytic infiltration suggests cellular source may be synoviocytes or fibroblasts, have distinctive pathogenetic roles human arthritis.