In Vivo Determination of Boron in Patients During BNCT in Petten by Means of the Gamma-Ray Telescope
作者： W. F. A. R. Verbakel , F. Stecher-Rasmussen
DOI: 10.1007/978-1-4615-1285-1_84
关键词: Nuclear medicine 、 In patient 、 Boron concentration 、 In vivo 、 Dosimetry 、 Irradiation 、 Boron 、 Dose group 、 Phase i study 、 Materials science 、 Radiochemistry
摘要: This study shows the feasibility of measuring an average boron concentration in head patient during BNCT irradiation by capture γ-ray spectroscopy. These measurements can be performed with y-ray telescope: a HPGe-detector outside therapy room, which measures γ-rays emitted through small hole ceiling. Until now, Petten Phase I study, 10 patients glioblastoma multiforme have been irradiated dose group 1. They were injected compound BSH about 12 hours before treatment. The tumour has debulked few weeks irradiation. Before and after irradiation, blood samples is determined prompt spectroscopy at neighbouring beam tube HB7 from samples. For proper dosimetry it also essential to know distribution 10B therapy.
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springerlink.com参考文章(3)
Advances in neutron capture therapy Plenum Press,New York (United States). ,(1993) , 10.1007/978-1-4615-2978-1
Weilian Yang, Rolf F. Barth, Joan H. Rotaru, Melvin L. Moeschberger, Darrel D. Joel, Marta M. Nawrocky, Joseph H. Goodman, Albert H. Soloway, Boron neutron capture therapy of brain tumors: Enhanced survival following intracarotid injection of sodium borocaptate with or without blood-brain barrier disruption International Journal of Radiation Oncology Biology Physics. ,vol. 37, pp. 663- 672 ,(1997) , 10.1016/S0360-3016(96)00082-X
Kanji MUKAI, Yoshinobu NAKAGAWA, Keizo MATSUMOTO, Prompt Gamma Ray Spectrometry for In Vivo Measurement of Boron-10 Concentration in Rabbit Brain Tissue Neurologia Medico-chirurgica. ,vol. 35, pp. 855- 860 ,(1995) , 10.2176/NMC.35.855