High prevalence and fixation of Plasmodium vivax dhfr/dhps mutations related to sulfadoxine/pyrimethamine resistance in French Guiana.
作者： Céline Barnadas , Didier Ménard , Christiane Bouchier , Stéphane Picot , Thierry Fusai
关键词: Sulfadoxine 、 Drug resistance 、 Pyrimethamine 、 Dihydropteroate synthase 、 Plasmodium vivax 、 Population 、 Biology 、 DHPS 、 Virology 、 Sulfadoxine/pyrimethamine
摘要: Plasmodium vivax isolates from French Guiana were studied for the presence of mutations associated with sulfadoxine/pyrimethamine (SP) drug resistance. Ninety-six blood samples collected 2000 to 2005 symptomatic malaria patients. SP resistance was predicted by determining point in dihydrofolate reductase (pvdhfr) and dihydropteroate synthase (pvdhps) genes. All showed mutant genotypes both genes a prevalence > 90% 58R, 117N, 382C, 383G. A new mutation (116G) pvdhfr found at frequency 3.3%. Six different pvdhfr/dhps multilocus observed predominance quintuple mutant-type 58R/117N/173L-382C/383G (59.3%). No significant differences between haplotypes year collection. Our results indicate that, this area, fixation drug-resistant parasites P. population is stable.
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