Plasmodium vivax Chloroquine Resistance and Anemia in the Western Brazilian Amazon

摘要: ABSTRACT Data on chloroquine (CQ)-resistant Plasmodium vivax in Latin America is limited, even with the current research efforts to sustain an efficient malaria control program all these countries where P. endemic and still a major public health issue. This study estimated vivo CQ resistance patients uncomplicated malaria, use of primaquine simultaneously, Brazilian Amazon. Of total 135 enrolled subjects who accomplished 28-day follow-up, parasitological failure was observed 7 (5.2%) patients, whom plasma desethylchloroquine (DCQ) concentrations were above 100 ng/dl. Univariate analysis showed that previous exposure higher initial mean parasitemia associated but not age or gender. In multivariate analysis, only high remained significant. Hemoglobin levels similar at beginning follow-up parasitemia. However, day 3 7, hemoglobin significantly lower presenting resistance. The dhfr ( pvdhfr ), pvmrp1 , pvmdr1 pvdhps gene mutations related this small sample. already problem Amazon, which could be some extent simultaneous report anemia triggered by parasite, common complication disease most areas endemicity.