Remarkable Functional Convergence: Alarmone ppGpp Mediates Persistence by Activating Type I and II Toxin-Antitoxins.
作者： Kenn Gerdes , Etienne Maisonneuve
DOI: 10.1016/J.MOLCEL.2015.06.019
关键词: Persistence (computer science) 、 Cell 、 Genetics 、 Biology 、 Second messenger system 、 GTP-binding protein regulators 、 Alarmone 、 Escherichia coli 、 Toxin 、 GTPase
摘要: In this issue of Molecular Cell, Verstraeten et al. (2015) demonstrate that the conserved GTPase Obg and second messenger ppGpp mediate persistence by activation a type I toxin-antitoxin module (hokB/sokB) in E. coli.
elsevier.com
sci-hub.se 参考文章(13)
K. Gerdes, F.W. Bech, S.T. Jørgensen, A. Løbner-Olesen, P.B. Rasmussen, T. Atlung, L. Boe, O. Karlstrom, S. Molin, K. von Meyenburg, Mechanism of postsegregational killing by the hok gene product of the parB system of plasmid R1 and its homology with the relF gene product of the E. coli relB operon. The EMBO Journal. ,vol. 5, pp. 2023- 2029 ,(1986) , 10.1002/J.1460-2075.1986.TB04459.X
S. Helaine, A. M. Cheverton, K. G. Watson, L. M. Faure, S. A. Matthews, D. W. Holden, Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters Science. ,vol. 343, pp. 204- 208 ,(2014) , 10.1126/SCIENCE.1244705
Boya Feng, Chandra Sekhar Mandava, Qiang Guo, Jie Wang, Wei Cao, Ningning Li, Yixiao Zhang, Yanqing Zhang, Zhixin Wang, Jiawei Wu, Suparna Sanyal, Jianlin Lei, Ning Gao, Structural and Functional Insights into the Mode of Action of a Universally Conserved Obg GTPase PLoS Biology. ,vol. 12, pp. e1001866- ,(2014) , 10.1371/JOURNAL.PBIO.1001866
K. Gerdes, P. B. Rasmussen, S. Molin, Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 3116- 3120 ,(1986) , 10.1073/PNAS.83.10.3116
Damián Lobato-Márquez, Inmaculada Moreno-Córdoba, Virginia Figueroa, Ramón Díaz-Orejas, Francisco García-del Portillo, Distinct type I and type II toxin-antitoxin modules control Salmonella lifestyle inside eukaryotic cells Scientific Reports. ,vol. 5, pp. 9374- 9374 ,(2015) , 10.1038/SREP09374
T. Ogura, S. Hiraga, Mini-F plasmid genes that couple host cell division to plasmid proliferation. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 80, pp. 4784- 4788 ,(1983) , 10.1073/PNAS.80.15.4784
Jan-Willem Veening, Wiep Klaas Smits, Oscar P. Kuipers, Bistability, epigenetics, and bet-hedging in bacteria. Annual Review of Microbiology. ,vol. 62, pp. 193- 210 ,(2008) , 10.1146/ANNUREV.MICRO.62.081307.163002
Etienne Maisonneuve, Manuela Castro-Camargo, Kenn Gerdes, (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity Cell. ,vol. 154, pp. 1140- 1150 ,(2013) , 10.1016/J.CELL.2013.07.048
Zachary D. Dalebroux, Sarah L. Svensson, Erin C. Gaynor, Michele S. Swanson, ppGpp Conjures Bacterial Virulence Microbiology and Molecular Biology Reviews. ,vol. 74, pp. 171- 199 ,(2010) , 10.1128/MMBR.00046-09
Etienne Maisonneuve, Kenn Gerdes, Molecular Mechanisms Underlying Bacterial Persisters Cell. ,vol. 157, pp. 539- 548 ,(2014) , 10.1016/J.CELL.2014.02.050