Distinct type I and type II toxin-antitoxin modules control Salmonella lifestyle inside eukaryotic cells

摘要: Toxin-antitoxin (TA) modules contribute to the generation of non-growing cells in response stress. These abound bacterial pathogens although bases for this profusion remain largely unknown. Using intracellular pathogen Salmonella enterica serovar Typhimurium as a model, here we show that selected group TA impact fitness inside eukaryotic cells. We characterized twenty-seven modules, including type I and II encoding antisense RNA proteinaceous antitoxins, respectively. Proteomic gene expression analyses revealed produces numerous toxins Among these, HokST, LdrAST, TisBST, encoded by T4ST VapC2ST, promote survival fibroblasts. In contrast, only VapC2ST shows positive effect when infects epithelial results illustrate how S. uses distinct regulate its lifestyle varied host cell types. This function specialization might explain why number increased pathogens.