Effects of Admission Hyperglycemia on Stroke Outcome in Reperfused Tissue Plasminogen Activator–Treated Patients

作者: José Alvarez-Sabín , Carlos A. Molina , Joan Montaner , Juan F. Arenillas , Rafael Huertas

DOI: 10.1161/01.STR.0000068406.30514.31

关键词: Modified Rankin ScaleStrokeThrombolysisSurgeryMiddle cerebral arteryInternal medicineTissue plasminogen activatorCardiologyTranscranial DopplerInfarctionT-plasminogen activatorMedicine

摘要: Background and Purpose—We sought to investigate the impact of hyperglycemia before reperfusion on long-term outcome in patients treated with intravenous tissue plasminogen activator (tPA). Methods—Of 268 consecutive patients with a nonlacunar middle cerebral artery (MCA) stroke evaluated at< 3 hours after onset, 73 (27.2%) received intravenous tPA. Serum glucose was determined at baseline before tPA administration. Hyperglycemia was defined as a glucose level> 140 mg/dL. National Institutes of Health Stroke Scale (NIHSS) …

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