Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice
作者： Nikhlesh K. Singh , Sivareddy Kotla , Elena Dyukova , James G. Traylor , A. Wayne Orr
DOI: 10.1038/NCOMMS8450
关键词: Interleukin 6 、 Internal medicine 、 Apolipoprotein B 、 Cell adhesion 、 PAK1 、 Endocrinology 、 Cell adhesion molecule 、 Biology 、 Motility 、 Cholesterol 、 Apolipoprotein E
摘要: Pak1 plays an important role in various cellular processes, including cell motility, polarity, survival and proliferation. To date, its atherogenesis has not been explored. Here we report the effect of on using atherosclerosis-prone apolipoprotein E-deficient (ApoE(-/-)) mice as a model. Disruption ApoE(-/-) results reduced plaque burden, significantly attenuates circulating IL-6 MCP-1 levels, limits expression adhesion molecules diminishes macrophage content aortic root mice. We also observed oxidized LDL uptake increased cholesterol efflux by macrophages smooth muscle cells ApoE(-/-):Pak1(-/-) compared with In addition, detect phosphorylation human atherosclerotic arteries, suggesting atherogenesis. Altogether, these identify factor initiation progression
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