Cardioprotective effect of Vitex negundo on isoproterenol-induced myocardial necrosis in wistar rats: A dual approach study.

摘要: Cardiovascular diseases (CVDs) are becoming the major cause of deaths worldwide, and their treatment demands novel therapeutic strategies. In this connection, we have identified p21 activated kinase 1 (PAK1) as a target for myocardial infarction (MI), where its expression is decreased when MI induced with isoproterenol (ISO), which was brought back normal pretreatment Vitex negundo leaf ethanolic extract (VNE). These results were also supported by histopathological studies, cardiac markers, antioxidants, inflammatory cytokines (NF-κB IL-1β). Further studies GC-MS analysis VNE in silico experiments confirmed 5,7-dihydroxy-6,4',-dimethoxy flavonone 3',5-dihydroxy-6,7,4',-trimethoxyflavone responsible either maintaining or inducing PAK1 to protect from MI. Our findings first time revealed use phytoconstituents