Effects of l-Tyrosine on working memory and inhibitory control are determined by DRD2 genotypes: A randomized controlled trial.
作者： Lorenza S. Colzato , Laura Steenbergen , Roberta Sellaro , Ann-Kathrin Stock , Larissa Arning
DOI: 10.1016/J.CORTEX.2016.06.010
关键词: Dopamine receptor D2 、 Neuroscience 、 C957T 、 Tyrosine 、 Psychology 、 Internal medicine 、 Cognition 、 Dopamine 、 Polymorphism (computer science) 、 Working memory 、 Genetic predisposition 、 Endocrinology
摘要: l-Tyrosine (TYR), the precursor of dopamine (DA), has been shown to enhance facets cognitive control in situations with high demands. However some previous outcomes were mixed: studies reported significant improvements, while other did not. Given that TYR increases DA level brain, we investigated, a double-blind, randomized, placebo-controlled design, whether C957T genotypes functional synonymous polymorphism human D2 receptor (DRD2) gene (rs6277) contribute individual differences reactivity administration and this factor predicts magnitude TYR-induced performance on inhibiting behavioral responses stop-signal task working memory (WM) updating N-back task. Our findings show T/T homozygotes (i.e., individuals potentially associated lower striatal level) showed larger beneficial effects supplementation than C/C higher level), suggesting genetically determined function may explain inter-individual response supplementation. These reinforce idea genetic predisposition modulates effect its role as enhancer.
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