Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases.

摘要: The fluorinated ornithine analog α-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of decarboxylase (ODC), the first and rate-limiting enzyme polyamine biosynthesis. ubiquitous essential polyamines have many functions, but are primarily important for rapidly proliferating cells. Thus, ODC potentially a drug target any disease state where rapid growth key process leading to pathology. compound was originally discovered as anticancer drug, its effectiveness disappointing. However, DFMO successfully developed treat African sleeping sickness currently one few clinically used drugs combat this neglected tropical disease. other Food Drug Administration (FDA) approved application active ingredient in hair removal cream Vaniqa. In recent years, renewed interest hyperproliferative diseases has led increased research promising preclinical clinical trials. This review explores use treatment hirsutism, well potential chemopreventive chemotherapeutic agent against colorectal cancer neuroblastoma.