Improved Prognostication of Renal Cell Carcinoma Using an Integrated Staging System
作者： Amnon Zisman , Allan J. Pantuck , Fredrick Dorey , Jonathan W. Said , Oleg Shvarts
DOI: 10.1200/JCO.2001.19.6.1649
关键词: Nephrectomy 、 Multivariate analysis 、 Performance status 、 Surgery 、 Carcinoma 、 Renal cell carcinoma 、 Survival analysis 、 Medicine 、 Stage (cooking) 、 Univariate analysis 、 Internal medicine 、 Oncology
摘要: PURPOSE: To integrate stage, grade, and Eastern Cooperative Oncology Group (ECOG) performance status (PS) into a clinically useful tool capable of stratifying the survival renal cell carcinoma (RCC) patients. PATIENTS AND METHODS: The medical records 661 patients undergoing nephrectomy at University California Los Angeles between 1989 1999 were evaluated. Median age was 61 years, male-to-female ratio 2.2:1, median follow-up 37 months. Survival time primary end point assessed. Sixty-four possible combinations ECOG PS analyzed collapsed distinct groups. internal validity categoriesd challenged by univariate analysis multivariate testing for accountability each UCLA Integrated Staging System (UISS) category against independent variables shown to have impact on survival. RESULTS: Combining 1997 tumor-node-metastasis Fuhrman’s grade resulted in five stratificati...
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