Computer simulations indicate that electrical field effects contribute to the shape of the epileptiform field potential.

摘要: Abstract In the presence of convulsant drugs such as picrotoxin, neurons in hippocampal-slice preparation generate synchronized depolarizing bursts. This synchrony occurs on a time scale tens milliseconds and is produced by excitatory synaptic interactions between neurons. The themselves occur milliseconds. “epileptiform” local-field potential during bursts comb-shaped (“ringing”), whereas field expected if action potentials neighboring were uncorrelated noisy not comb-shaped. suggests that individual are locally 1 ms. We have previously shown, using computer simulations, electrical interactions—mediated currents flowing extracellular medium—can plausibly explain action-potential synchronization experiments where chemical synapses blocked. present simulations demonstrate can also account for synchronization—and thus “ringing” shape potential—during epileptiform bursts, functional. modulating influence on, well reflection of, underlying neuronal transmembrane events.