Protective effects of monoclonal antibodies against lethal canine distemper virus infection in mice.
作者： N. Hirayama , M. Senda , N. Nakashima , M. Takagi , M. Sugiyama
DOI: 10.1099/0022-1317-72-11-2827
关键词: Paramyxoviridae 、 Biology 、 Antibody 、 Cell fusion 、 Virology 、 Canine distemper 、 Monoclonal antibody 、 Virus 、 Neutralization 、 Epitope
摘要: Monoclonal antibodies (MAbs) against the haemagglutinin (H), fusion protein (F) and nucleoprotein of canine distemper virus (CDV) were examined for their ability to protect mice lethal CDV infection. One MAb H two six MAbs F protected mice, protective effect anti-H being stronger than that anti-F MAbs. The showed neutralizing activity, but MAbs, which recognized same epitope, did not. Protection by correlated with cell inhibition, not complement-dependent neutralization, cytolysis or antibody-dependent cell-mediated cytotoxicity. These results suggest neutralization antibody inhibition play important roles in mechanism
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