A case of multiple synchronous lung adenocarcinomas with differing EGFR mutations
作者： Hideomi Hasegawa , Hideki Kimura , Masato Shingyoji , Makiko Itami , Akinobu Araki
DOI: 10.1007/S13691-013-0096-8
关键词: Tyrosine kinase 、 Pathology 、 Lung cancer 、 Surgical oncology 、 Epidermal growth factor receptor 、 Medicine 、 Adenocarcinoma 、 Mutation 、 Lung 、 Segmental resection
摘要: We report a case of four synchronous lung cancers, each with different epidermal growth factor receptor (EGFR) mutation in the tyrosine kinase domain. Bilateral double cancer was diagnosed clinically, and left upper lobectomy partial S6 resection were performed. Right S1 segmental performed later. Pathological examination revealed three adenocarcinomas (S1 + 2, S3, S6) one right. Three mutations EGFR identified polymerase chain reaction direct sequencing DNA from tumors. The on right also differed that
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