Genetic Heterogeneity in Patients with Multiple Neoplastic Lung Lesions: A Report of Three Cases
作者： Mariëlle I. Gallegos Ruiz , Hester van Cruijsen , Egbert F. Smit , Katrien Grünberg , Gerrit A. Meijer
DOI: 10.1016/S1556-0864(15)30012-5
关键词:
摘要: Introduction: It is important to determine the relation among various lesions in patients presenting with multiple malignant lung tumors define best treatment approach. A better understanding of molecular alterations present different may help defining this relation. Methods: We performed a detailed analysis several tumor specimens obtained from three lesions. Tumor were analyzed for epidermal growth factor receptor (EGFR) and k-ras mutations by direct DNA sequencing. In addition, genome-wide chromosomal copy number was on extracted using array-based comparative genomic hybridization. Results: one case, deletion 15 base pairs exon 19 EGFR all sites analyzed. Furthermore, similar pattern aberrations observed lesions, suggesting that they share same clonal origin. other two cases, contrast, we identified distinct genotypes patient. These moreover, showed aberration patterns, indicating have underlying pathways tumorigenesis. Conclusion: Our results show mutation analysis, combined profiling, can relationship
jto.org
vumc.nl
narcis.nl
elsevier.com参考文章(21)
Paul van den IJssel, Marianne Tijssen, Suet-Feung Chin, Paul Eijk, Beatriz Carvalho, Erik Hopmans, Henne Holstege, Dhinoth Kumar Bangarusamy, Jos Jonkers, Gerrit A Meijer, Carlos Caldas, Bauke Ylstra, None, Human and mouse oligonucleotide-based array CGH Nucleic Acids Research. ,vol. 33, ,(2005) , 10.1093/NAR/GNI191
Branislav Jeremic, Yuta Shibamoto, Ljubisa Acimovic, Nebojsa Nikolic, Aleksandar Dagovic, Jasna Aleksandrovic, Gordana Radosavljevic-Asic, Second Cancers Occurring in Patients With Early Stage Non–Small-Cell Lung Cancer Treated With Chest Radiation Therapy Alone Journal of Clinical Oncology. ,vol. 19, pp. 1056- 1063 ,(2001) , 10.1200/JCO.2001.19.4.1056
Ximing Tang, Hisayuki Shigematsu, B. Nebiyou Bekele, Jack A. Roth, John D. Minna, Waun Ki Hong, Adi F. Gazdar, Ignacio I. Wistuba, EGFR Tyrosine Kinase Domain Mutations Are Detected in Histologically Normal Respiratory Epithelium in Lung Cancer Patients Cancer Research. ,vol. 65, pp. 7568- 7572 ,(2005) , 10.1158/0008-5472.CAN-05-1705
William H. Westra, Robbert J. C. Slebos, G. Johan A. Offerhaus, Steven N. Goodman, Siegina G. Evers, Thomas W. Kensler, Frederic B. Askin, Sjoerd Rodenhuis, Ralph H. Hruban, K-ras oncogene activation in lung adenocarcinomas from former smokers. Evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung Cancer. ,vol. 72, pp. 432- 438 ,(1993) , 10.1002/1097-0142(19930715)72:2<432::AID-CNCR2820720219>3.0.CO;2-#
Daniel Pinkel, Donna G Albertson, Array comparative genomic hybridization and its applications in cancer Nature Genetics. ,vol. 37, pp. S11- S17 ,(2005) , 10.1038/NG1569
Frederic M Waldman, Sandy DeVries, Karen L Chew, Dan H Moore, Karla Kerlikowske, Britt-Marie Ljung, Chromosomal alterations in ductal carcinomas in situ and their in situ recurrences. Journal of the National Cancer Institute. ,vol. 92, pp. 313- 320 ,(2000) , 10.1093/JNCI/92.4.313
Jeng-Kai Jiang, Yann-Jang Chen, Chi-Hung Lin, I-Ting Yu, Jen-Kou Lin, Genetic changes and clonality relationship between primary colorectal cancers and their pulmonary metastases—An analysis by comparative genomic hybridization Genes, Chromosomes and Cancer. ,vol. 43, pp. 25- 36 ,(2005) , 10.1002/GCC.20167
M. M. Weiss, M. A. Hermsen, G. A. Meijer, N. C. van Grieken, J. P. Baak, E. J. Kuipers, P. J. van Diest, Comparative genomic hybridisation. Molecular pathology : MP. ,vol. 52, pp. 243- 251 ,(1999) , 10.1136/MP.52.5.243
Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella, Sarada Gurubhagavatula, Ross A. Okimoto, Brian W. Brannigan, Patricia L. Harris, Sara M. Haserlat, Jeffrey G. Supko, Frank G. Haluska, David N. Louis, David C. Christiani, Jeff Settleman, Daniel A. Haber, Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib The New England Journal of Medicine. ,vol. 350, pp. 2129- 2139 ,(2004) , 10.1056/NEJMOA040938
M Sagawa, Y Saito, S Fujimura, RI Linnoila, K-ras point mutation occurs in the early stage of carcinogenesis in lung cancer British Journal of Cancer. ,vol. 77, pp. 720- 723 ,(1998) , 10.1038/BJC.1998.118