Bone marrow cells carrying the env-pX transgene play a role in the severity but not prolongation of arthritis in human T-cell leukaemia virus type-I transgenic rats: a possible role of articular tissues carrying the transgene in the prolongation of arthritis.
作者： Asami Abe , Akihiro Ishizu , Hitoshi Ikeda , Hiroko Hayase , Takahiro Tsuji
DOI: 10.1111/J.0959-9673.2004.00384.X
关键词: Synovial membrane 、 Immunology 、 Arthritis 、 Bone marrow 、 Cytokine 、 Medicine 、 Interleukin 6 、 Transplantation 、 Type II collagen 、 Leukemia
摘要: Transgenic rats carrying the env-pX gene of human T-cell leukaemia virus type-I (env-pX rats) were immunized with type II collagen (CII), and chronological alterations arthritis compared findings collagen-induced (CIA) in wildtype Wistar-King-Aptekman-Hokudai (WKAH) rats. Arthritis induced by CII was more severe persisted longer than CIA WKAH To determine whether phenomenon is caused mainly transgene-carrying lymphocytes or articular tissues, we lethally irradiated reciprocal bone marrow cell (BMC) transplantation. A but transient reconstituted BMC (w/tB/CII rats). On other hand, BMC, w/tB/CII rats, although degree less at an early phase after immunization. These suggest that tissues rather BMCs transgene play a role prolongation are associated severity arthritis. When inflammatory cytokines synovial cells isolated from before they developed examined, interleukin-6 (IL-6) detected higher level thus suggesting critical IL-6
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