NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster.

摘要: Nuclear Factor-κB (NF-κB)/Rel transcription factors form an integral part of innate immune defenses and are conserved throughout the animal kingdom. Studying function, mechanism activation regulation these is crucial for understanding host responses to microbial infections. The fruit fly Drosophila melanogaster has proved be a valuable model system study evolutionarily NF-κB mediated responses. combats pathogens through humoral cellular These well characterized marked by robust production battery anti-microbial peptides. Two signaling pathways, Toll IMD responsible induction antimicrobial Signal transduction in pathways strikingly similar that mammalian TLR pathways. In this chapter, we discuss detail molecular mechanisms recognition, signal regulation, both Similarities differences relative their counterparts discussed, recent advances our intricate regulatory networks also highlighted.