Identification and characterization of circular RNAs involved in mechanical force-induced periodontal ligament stem cells.

摘要: Circular RNAs (circRNAs) play critical roles in signal transduction during cell proliferation, differentiation, and apoptosis a posttranscriptional manner. Recently, circRNAs have been proved to be large class of animal with regulatory potency. However, whether can respond mechanical force (MF) impact on human periodontal ligament stem cells (PDLSCs) the orthodontic tooth movement (OTM) process remain unknown. Here, we investigated expression patterns PDLSCs induced by MF found that were responsive PDLSCs. Through valid reads' distribution analysis, majority reads both control MF-induced distributed exons. Then analyzed Gene Ontology terms genes overlap or are neighbors stress-responsive unique enrichment biological processes, molecular function, cellular component Next, predicted possible functions through circRNAs-miRNAs networks. We one circRNA may regulate several miRNA/miRNAs miRNA interact multiple circRNA/circRNAs. Importantly, number directly indirectly miRNAs-mediated osteogenic differentiation mesenchymal cells. For instance, circRNA3140 was highly widely associated microRNA-21, which plays role Taken together, these findings reveal previously unrecognized mechanism induce changes PDLSCs, modulate OTM alveolar bone remodeling.