Deep latency: A new insight into a functional HIV cure

摘要: Latent HIV reservoir is the main obstacle that prevents a cure for HIV-1 (HIV). While antiretroviral therapy effective in controlling viral replication, it cannot eliminate latent reservoirs patients. Several strategies have been proposed to combat latency, including bone marrow transplantation replace blood cells with CCR5-mutated stem cells, gene editing disrupt genome, and "Shock Kill" reactivate followed by an immune clearance. However, high risks limitations scale-up clinics, off-target effects human genomes or failure reduce sizes patients hampered our current efforts achieve cure. This necessitates alternative control reservoirs. review will discuss emerging strategy aimed deeply silence reservoirs, development of this concept, its potential caveats remission/cure, prospective directions silencing HIV, thereby preventing viruses from rebound.