Chapter 12. Synthetic Antibacterial Agents

摘要: Publisher Summary Infectious drug resistance denotes the transmission of from one bacterium (so far only Gram-negatives) to another same or different strain, species, genus. This is accomplished by conjugation that leads directly a new recipient strain with comparable level resistance. The surprising facet this phenomenon simultaneous transfer an entire series chemically and biochemically unrelated antimicrobials; most commonly in sulfanilamides, tetracyclines, streptomycin, chloramphenicol, but also more recently penicillins, kanamycin, neomycin, nalidixic acid, nitrofurans. Resistant bacteria can be stripped infectious various acridines vitro , albeit low frequency; usually method applies all factors, some segregation has been achieved. Several sulfanilamides other synthetic antibacterials as well antibiotics are involved No antibacterial screening methods reported. Recent success experimental animals growing leprosy bacillus led significant promising additions field. Over 100 Myco leprae strains over world several clinical types have now produced mouse foot-pad infections. relationship bacterial morphology, administration antileprotic agents, BCG vaccination, immune-response suppression production increased infectivity mice studied.