Chapter 11. Synthetic Antibacterial Agents

摘要: Publisher Summary This chapter provides a review of synthetic antibacterial agents. Systemic agents have been reviewed and the topical in vitro active compounds unproven systemic potential are elaborated. Compounds with activity against tubercle bacillus discussed other antituberculous The effect nalidixic acid on cell free systems suggests that site action for DNA intact is masked or absent systern. In testing was reported semicarbazones thiosemicarbazones nitrofurfuraldehyde, N -substituted nitrofurantoin, methylpyrazoles, aryltetrazoles, carbonyl substituted isoxazoles, oxadiazolines, aminocyanoisoxazoles imidazolopyridine, fused ring imidazole compounds. Nitrothio-phenealdehyde acetals, semicarbazones, were compared analogous nitrofurfuraldehyde derivatives. polymeric hydrazone from polyacryloylhydrazide but not absorbed perorally. A toxic reaction new to sulfas discovered 3- sulfanilamido-6-ethoxypyridazine. On prolonged feeding at high doses, it causes cataracts dogs rats.