Heparin after percutaneous intervention (HAPI): a prospective multicenter randomized trial of three heparin regimens after successful coronary intervention

摘要: OBJECTIVES The purpose of this study was to determine the incidence bleeding, vascular, and ischemic complications using three different heparin regimens after successful intervention. BACKGROUND ideal dose duration infusion coronary intervention is unknown. METHODS Patients were randomized one strategies intervention: Group 1 (n = 157 patients) received prolonged (12 24 h) followed by sheath removal; 2 120 underwent early removal sheaths, reinstitution for 12 18 h; 3 137 did not receive any further with removal. primary end point combined in-hospital bleeding vascular events. Secondary points included events, length stay, cost one-month outcome. RESULTS After intervention, 414 patients randomized. Unstable angina or postinfarction present in 83% before events 21% 1, 14% 8% (p 0.01). overall 2.2%; there no differences between groups. Length hospital stay shorter 0.033) adjusted lower < 0.001) 3. At 30 days, delayed cardiac similar all CONCLUSIONS Heparin associated more minor injury, increased cost. In-hospital rarely occur irrespective use. Routine postprocedure recommended, even who unstable syndromes.