Unfractionated heparin use after percutaneous coronary intervention: results of a trial with a vascular ultrasound endpoint.

摘要: Background Previous studies in the pre-stent era have evaluated postprocedural use of unfractionated heparin (UFH) on clinically defined vascular complications and ischaemic cardiac complications. We prospectively benefits risks this practice, using ultrasound determined endpoints current stent era. Methods Patients undergoing percutaneous coronary intervention (PCI) enrolled two our previous routine prospective were included analysis. Generally decision to UFH after sheath removal was at discretion operator, however a subset patients randomised receive or not. Femoral performed prior hospital discharge interpreted by an experienced ultrasonographer blinded whether used The primary endpoint composite significant including major haematoma, pseudoaneurysm, arterio-venous fistula, femoral venous arterial thrombosis retroperitoneal haemorrhage. Secondary events, length stay outcome 30 days. Results A total 530 (43% receiving UFH) incidence for entire population 4.0% both no groups ( p =1.00). In 226 (43%), patient subset, occurred 5.2% group 4.5% =0.80). Time ambulation similar groups. At days, adverse events (4.7% cohort) all Conclusions When is determine PCI not associated with increased also failed provide evidence meaningful clinical benefit selected cohort.