The ocular hypertensive response following experimental acid burns in the rabbit eye.

摘要: Following application of 50 microliter 2N hydrochloric acid to the rabbit cornea, intraocular pressure rapidly increases and remains markedly elevated for up 3 hr. The initial rapid increase in appears be result acid-induced shrinkage outer collagenous coats eye. sustained rise is mediated part by prostaglandin release. Increased prostaglandin-like activity, determined aqueous after an burn, was greatly inhibited pretreatment rabbits with indomethacin a much lesser extent imidazole. Both imidazole essentially abolished elevation burn. Analysis changes pH protein level implies that stimulus prostaglanding release within eye penetration hydrogen ions into humor, resultant trauma.