HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer

作者: Alan Engelman , Kiyoshi Mizuuchi , Robert Craigie

DOI: 10.1016/0092-8674(91)90297-C

关键词: In vitro recombinationDNA ligaseDNA clampBiologyStereochemistryVirus IntegrationDNA polymerase IIMolecular biologyDNA supercoilDNA IntegrationBase pair

摘要: Retroviral DNA integration involves a coordinated set of DNA cutting and joining reactions. Linear viral DNA is cleaved at each 3′ end to generate the precursor ends for integration. …

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