The impact of atherosclerotic vascular disease in predicting a stroke, thromboembolism and mortality in atrial fibrillation patients: a systematic review

摘要: Summary Background Atrial fibrillation (AF) is commonly associated with vascular disease. Although atherosclerotic disease (for example, defined as a myocardial infarction (MI), complex aortic plaque and peripheral arterial disease) has been proposed risk factor for stroke, the co-existence of two diseases increases future cardiovascular events. The objective this study was to conduct systematic review assess impact on primary end-point thromboembolism or mortality, in patients AF. Methods Literature searches were performed electronically, identify studies published between January 1990and July 2012 examining stroke relation AF Nineteen articles satisfied pre-inclusion criteria. bibliographies subsequently screened retrieve further relevant review. Results Peripheral significantly increased all 10 observational studies, within reported range 1.3- 2.5-fold. Complex descending aorta, identified by trans-oesophageal echocardiography, also significant factor. prior (MI) validated predictor amongst five six there degree heterogeneity, owing marked difference population sizes use antithrombotic regimens studies. Conclusion Atherosclerotic (e.g. disease, MI) are predictors mortality subjects AF.