Ankle brachial index as an independent predictor of mortality in anticoagulated atrial fibrillation

摘要: Eur J Clin Invest 2012; 42 (12): 1302–1308 Abstract Background  An abnormal ankle brachial index (ABI, the ratio of and systolic blood pressure) (≤ 0·90 or ≥ 1·4) suggests presence peripheral arterial disease (PAD) has proposed as a marker cardiovascular risk. We hypothesised that ABI would predict mortality adverse events in anticoagulated chronic nonvalvular AF patients. Methods  recruited 287 consecutive outpatients with permanent paroxysmal who were stabilised for 6 months on oral anticoagulation (Oral anticoagulation; INR 2·0–3·0). was performed following standard technique. Cox models used to determine association between ABI, bleeding, mortality. Results  Median 1·09 (0·93–1·23) 78 (27%) had an ABI. Abnormal associated diabetes, heart failure ischaemic (P = 0·006, 0·019 0·009, respectively), CHADS2 score ≥ 2 (P = 0·016). follow-up 861 (718–1016) days, during 21(7%) presented event, 23 (8%) major bleeding 18 (6%) died. independent predictor all-cause mortality, even after adjusting score (Cox multivariable regression analysis, HR 2·76(1·08–7·06), P = 0·033). significantly haemorrhagic [HR: 2·47(1·01–6·04); P = 0·047], adjustment HAS-BLED score. Conclusion  is common patients, score. could be useful tool improving risk stratification patients.