Seizure Correlates with Prolonged Hospital Stay, Increased Costs, and Increased Mortality in Nontraumatic Subdural Hematoma

作者: Jacob R Joseph , Brandon W Smith , Craig A Williamson , Paul Park , None

DOI: 10.1016/J.WNEU.2016.05.033

关键词: PediatricsHospital stayPopulationEpilepsyIntensive care unitPatient demographicsSurgeryIndirect costsHematomaRetrospective cohort studyMedicine

摘要: Background Nontraumatic subdural hematoma (NTSDH) is a common neurosurgical disease process, with mortality reported as high 13%. Seizure has known association NTSDH, although patient outcomes have not previously been well studied in this population. The purpose of study was to examine the relationship between in-hospital seizure and inpatient NTSDH. Methods Using University HealthSystem Consortium (UHC) database, we performed retrospective cohort adults principal diagnosis NTSDH ( International Classification Diseases, Ninth Revision code 43.21) 2011 2015. Patients codes 34500–34591, 78033, 78039) were compared those without. history before arrival excluded. Patient demographics, hospital length stay (LOS), intensive care unit stay, mortality, direct costs recorded. Results A total 16,928 patients identified. Mean age 69.2 years, 64.7% male. In-hospital documented 744 (4.40%) patients. Hospital LOS 17.64 days 6.26 without P Conclusions correlates significantly increased mortality. Direct are similarly increased. Further studies accounting for effects illness severity necessary validate these results.

参考文章(16)
Fabrice Battaglia, Benjamin Plas, Anthony Melot, Rémy Noudel, Jean-Christophe Sol, Pierre-Hugues Roche, Vincent Lubrano, Is there any benefit from short-term perioperative antiepileptic prophylaxis in patients with chronic subdural haematoma? A retrospective controlled study. Neurochirurgie. ,vol. 61, pp. 324- 328 ,(2015) , 10.1016/J.NEUCHI.2015.06.004
Alejandro A. Rabinstein, Seung Young Chung, Leslie A. Rudzinski, Giuseppe Lanzino, Seizures after evacuation of subdural hematomas: incidence, risk factors, and functional impact. Journal of Neurosurgery. ,vol. 112, pp. 455- 460 ,(2010) , 10.3171/2009.7.JNS09392
Bernardo O Ratilal, Lia Pappamikail, João Costa, Cristina Sampaio, Anticonvulsants for preventing seizures in patients with chronic subdural haematoma. Cochrane Database of Systematic Reviews. ,(2013) , 10.1002/14651858.CD004893.PUB3
Yu-Hua Huang, Tzu-Ming Yang, Yu-Jun Lin, Nai-Wen Tsai, Wei-Che Lin, Hung-Chen Wang, Wen-Neng Chang, Cheng-Hsien Lu, Risk Factors and Outcome of Seizures After Chronic Subdural Hematoma Neurocritical Care. ,vol. 14, pp. 253- 259 ,(2011) , 10.1007/S12028-011-9509-8
Adrian L. Rabinowicz, Jorge D. Correale, Kirsten A. Bracht, Thomas D. Smith, Christopher M. DeGiorgio, Neuron-Specific Enolase Is Increased After Nonconvulsive Status Epilepticus Epilepsia. ,vol. 36, pp. 475- 479 ,(1995) , 10.1111/J.1528-1157.1995.TB00489.X
John P Betjemann, Daniel H Lowenstein, Status epilepticus in adults Lancet Neurology. ,vol. 14, pp. 615- 624 ,(2015) , 10.1016/S1474-4422(15)00042-3
Robert A. Sabo, William C. Hanigan, Jean C. Aldag, Chronic subdural hematomas and seizures: the role of prophylactic anticonvulsive medication. Surgical Neurology. ,vol. 43, pp. 579- 582 ,(1995) , 10.1016/0090-3019(95)00155-7
James Tsai, Karon Abe, Sheree L. Boulet, Michele G. Beckman, W. Craig Hooper, Althea M. Grant, Predictive Accuracy of 29-Comorbidity Index for In-Hospital Deaths in US Adult Hospitalizations with a Diagnosis of Venous Thromboembolism PLoS ONE. ,vol. 8, pp. e70061- ,(2013) , 10.1371/JOURNAL.PONE.0070061
M Erik von Elm, Douglas G Altman, Matthias Egger, Stuart J Pocock, Peter C Gøtzsche, Jan P Vandenbroucke, None, The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies Annals of Internal Medicine. ,vol. 147, pp. 573- 577 ,(2007) , 10.7326/0003-4819-147-8-200710160-00010
C. M. DeGiorgio, J. D. Correale, P. S. Gott, D. L. Ginsburg, K. A. Bracht, T. Smith, R. Boutros, W. J. Loskota, A. L. Rabinowicz, Serum neuron‐specific enolase in human status epilepticus Neurology. ,vol. 45, pp. 1134- 1137 ,(1995) , 10.1212/WNL.45.6.1134