Tosylate salt of 6- (4-br0m0-2-chl0r0phenylamin0) -7-fluoro-n- (2-hydroxyethoxy) -3-methyl-3h-benzimi dazole- 5 - carboxamide , mek inhibitor useful in the treatment of cancer
作者： Richard Anthony Storey , Mohammed Pervez , Ronald John Roberts , Christopher John Squire
DOI:
关键词: Active ingredient 、 Stereochemistry 、 Animal body 、 Combinatorial chemistry 、 Cancer 、 Carboxamide 、 Proliferative disease 、 Salt (chemistry) 、 MEK inhibitor 、 Chemistry
摘要: The present invention relates to a tosylate salt of Compound 1 t and polymorphs thereof, in particular crystalline amorphous forms salt, methods preparation thereof. Pharmaceutical compositions containing these salts as active ingredient, their use the manufacture medicaments for treatment and/or prophylaxis proliferative disease states, such cancer, human or animal body, body are also described.
lens.org 参考文章(1)
Allison L. Marlow, Eli M. Wallace, Brian T. Hurley, Joseph P. Lyssikatos, N3 alkylated benzimidazole derivatives as MEK inhibitors ,(2003)