Comparison of the brain levels of N,N-dimethyltryptamine and alpha, alpha, beta, beta-tetradeutero-N-N-dimethyltryptamine following intraperitoneal injection. The in vivo kinetic isotope effect.
作者： Steven A. Barker , John M. Beaton , Samuel T. Christian , John A. Monti , Philip E. Morris
DOI: 10.1016/0006-2952(82)90062-4
关键词: Pharmacology 、 Metabolism 、 Alpha (ethology) 、 Ethylamine 、 Intraperitoneal injection 、 Stereochemistry 、 In vivo 、 Beta (finance) 、 Chemistry 、 Hallucinogen 、 N,N-Dimethyltryptamine
摘要: A comparison of the brain levels (microgram/g wet weight tissue) hallucinogen N,N-dimethyltryptamine (DMT) and its deuterated analog alpha, beta, beta-tetradeutero-DMT (D4DMT) as a function time dose is reported. It was observed that presence deuterium in alpha- beta-positions ethylamine side-chain led to potentiation level DMT brain. Strikingly different dynamics uptake clearance were also noted. We propose these results are due primary kinetic isotope effect, illustrating importance alpha-position metabolism DMT.
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sci-hub.se 参考文章(13)
Steven A. Barker, John A. Monti, Samuel T. Christian, N,N-Dimethyltryptamine: An Endogenous Hallucinogen International Review of Neurobiology. ,vol. 22, pp. 83- 110 ,(1981) , 10.1016/S0074-7742(08)60291-3
Brown Gb, Smythies, Morin Rd, Identification of dimethyltryptamine and O-methylbufotenin in human cerebrospinal fluid by combined gas chromatography/mass spectrometry. Biological Psychiatry. ,vol. 14, pp. 549- ,(1979)
T. E. Smith, H. Weissbach, S. Udenfriend, Studies on the mechanism of action of monoamine oxidase: metabolism of N,N-dimethyltryptamine and N,N-dimethyltryptamine-N-oxide. Biochemistry. ,vol. 1, pp. 137- 143 ,(1962) , 10.1021/BI00907A021
S.A. Barker, R.E. Harrison, G.B. Brown, S.T. Christian, Gas chromatographic/mass spectrometric evidence for the identification of 1,2,3,4-tetrahydro-β-carboline as an invivo constituent of rat brain Biochemical and Biophysical Research Communications. ,vol. 87, pp. 146- 154 ,(1979) , 10.1016/0006-291X(79)91659-0
Steven A. Barker, John A. Monti, Samuel T. Christian, Metabolism of the hallucinogen N,N-dimethyltryptamine in rat brain homogenates. Biochemical Pharmacology. ,vol. 29, pp. 1049- 1057 ,(1980) , 10.1016/0006-2952(80)90169-0
P. JENNER, C.D. MARSDEN, C.M. THANKI, BEHAVIOURAL CHANGES INDUCED BY N,N‐DIMETHYLTRYPTAMINE IN RODENTS British Journal of Pharmacology. ,vol. 69, pp. 69- 80 ,(1980) , 10.1111/J.1476-5381.1980.TB10884.X
Beng T. Ho, William M. McIsaac, Rong An, Robert T. Harris, K. E. Walker, Patricia M. Kralik, Mauno M. Airaksinen, Biological activities of some 5-substituted N,N-dimethyltryptamines, alpha-methyltryptamines, and gramines. Psychopharmacology. ,vol. 16, pp. 385- 394 ,(1970) , 10.1007/BF00404849
Martin I. Blake, Henry L. Crespi, Joseph J. Katz, Studies with Deuterated Drugs Journal of Pharmaceutical Sciences. ,vol. 64, pp. 367- 391 ,(1975) , 10.1002/JPS.2600640306
S.T. Christian, F. Benington, R.D. Morin, L. Corbett, Gas-liquid chromatographic separation and identification of biologically important indolealkylamines from human cerebrospinal fluid Biochemical Medicine. ,vol. 14, pp. 191- 200 ,(1975) , 10.1016/0006-2944(75)90036-8
Wm. M. Govier, B. G. Howes, A. J. Gibbons, The oxidative deamination of serotonin and other 3-(beta-aminoethyl)-indoles by monamine oxidase and the effect of these compounds on the deamination of tyramine. Science. ,vol. 118, pp. 596- 597 ,(1953) , 10.1126/SCIENCE.118.3072.596