Distribution of the hallucinogens N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine in rat brain following intraperitoneal injection: application of a new solid-phase extraction LC-APcI-MS-MS-isotope dilution method.
作者： Steven A Barker , Martha A Littlefield-Chabaud , Connie David
DOI: 10.1016/S0378-4347(00)00442-4
关键词:
摘要: A method for the solid-phase extraction (SPE) and liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometric-mass spectrometric-isotope dilution (LC-APcI-MS-MS-ID) analysis of indole hallucinogens N,N-dimethyltryptamine (DMT) 5-methoxy DMT (or O-methyl bufotenin, OMB) from rat brain tissue is reported. Rats were administered or OMB by intraperitoneal route at a dose 5 mg/kg sacrificed 15 min post treatment. Brains dissected into discrete areas analyzed methods described as demonstration procedure's applicability. The synthesis use two new deuterated internal standards these purposes are also
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sci-hub.se 参考文章(61)
A test of the transmethylation hypothesis in acute schizophrenic patients. American Journal of Psychiatry. ,vol. 132, pp. 1067- 1071 ,(1975) , 10.1176/AJP.132.10.1067
Steven A. Barker, John A. Monti, Samuel T. Christian, N,N-Dimethyltryptamine: An Endogenous Hallucinogen International Review of Neurobiology. ,vol. 22, pp. 83- 110 ,(1981) , 10.1016/S0074-7742(08)60291-3
Brown Gb, Smythies, Morin Rd, Identification of dimethyltryptamine and O-methylbufotenin in human cerebrospinal fluid by combined gas chromatography/mass spectrometry. Biological Psychiatry. ,vol. 14, pp. 549- ,(1979)
Daniel M. Perrine, The Chemistry of Mind-Altering Drugs: History, Pharmacology, and Cultural Context ,(1996)
Steven A. Barker, John M. Beaton, Samuel T. Christian, John A. Monti, Philip E. Morris, Comparison of the brain levels of N,N-dimethyltryptamine and alpha, alpha, beta, beta-tetradeutero-N-N-dimethyltryptamine following intraperitoneal injection. The in vivo kinetic isotope effect. Biochemical Pharmacology. ,vol. 31, pp. 2513- 2516 ,(1982) , 10.1016/0006-2952(82)90062-4
H V Vunakis, L J Riceberg, Determination of N,N-dimethylindolealkylamines in plasma, blood and urine extracts by radioimmunoassay and high pressure liquid chromatography. Journal of Pharmacology and Experimental Therapeutics. ,vol. 206, pp. 158- 166 ,(1978)
David S. Wishart, Brian D. Sykes, Frederic M. Richards, Improved synthetic methods for the selective deuteration of aromatic amino acids : applications of selective protonation towards the identification of protein folding intermediates through nuclear magnetic resonance Biochimica et Biophysica Acta. ,vol. 1164, pp. 36- 46 ,(1993) , 10.1016/0167-4838(93)90109-5
M.F. Balandrin, A.D. Kinghorn, S.J. Smolenski, R.H. Dobberstein, Reversed-phase high-pressure liquid chromatography of some tryptamine derivatives Journal of Chromatography A. ,vol. 157, pp. 365- 370 ,(1978) , 10.1016/S0021-9673(00)92354-9
Martti Räisänen, Jorma Kärkkäinen, Mass fragmentographic quantification of urinary N,N-dimethyltryptamine and bufotenine. Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 162, pp. 579- 584 ,(1979) , 10.1016/S0378-4347(00)81837-X
R.W. Walker, H.S. Ahn, G. Albers-Schönberg, L.R. Mandel, W.J.A. Vandenheuvel, Gas chromatographic-mass spectrometric isotope dilution assay for N,N-dimethyltryptamine in human plasma Biochemical Medicine. ,vol. 8, pp. 105- 113 ,(1973) , 10.1016/0006-2944(73)90014-8