Scarless wound healing in the mammalian fetus.

摘要: Fetal wound healing is a remarkable process that fundamentally different than postnatal healing. Healing of primarily closed, linear wounds occurs rapidly and without scarring. In late gestational age fetal sheep, transition to adult-like as evidenced by minimal scar formation. Acute inflammation not involved, fibroblast recruitment proliferation minimal, the matrix enriched with HA collagen deposition highly organized so scarring or nonexistent. Open in several species do contract, an observation may be because inhibitor contraction amniotic fluid. The underlying mechanisms regulate repair are currently well understood. An altered supply activity growth factors instrumental. Fibroblasts preferentially produce secondary factor present within system, influence cellular events wound. As greater knowledge biologic scarless fetus gained, applications abnormal adult developed. surgery approaching, it essential understand injury response these new patients.